After slowing skye, you can kill her easily, make sure, when she tries to turn invisible shoot a projectile to the ground, the blast will kill her. I recomend Catalyst legandary!
If you are crippled go to counter stance. The enemy will either not attack or if they do you can counter the damage. No matter what this will give you JUST ENOUGH time to escape the cripple and use billow to retreat
Remember to get rid of enemy deployables especially Barik's turrets and even more when he has the turret legendary card. They are not something to be ignored because when they are you don't realize when you are getting damaged
Someone recently mentioned that when Ruckus uses his ult he can't move so use Jenos' ult then. Even if you do that it won't kill him since he's a high health tank unless he already has half of his health down. Instead see if your enemies are cornered